KMID : 0620920210530091278
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Experimental & Molecular Medicine 2021 Volume.53 No. 9 p.1278 ~ p.1286
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Unraveling the physiological roles of retinoic acid receptor-related orphan receptor ¥á
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Lee Ji-Min
Kim Hyun-Kyung Baek Sung-Hee
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Abstract
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Retinoic acid receptor-related orphan receptor-¥á (ROR¥á) is a member of the orphan nuclear receptor family and functions as a transcriptional activator in response to circadian changes. Circadian rhythms are complex cellular mechanisms regulating diverse metabolic, inflammatory, and tumorigenic gene expression pathways that govern cyclic cellular physiology. Disruption of circadian regulators, including ROR¥á, plays a critical role in tumorigenesis and facilitates the development of inflammatory hallmarks. Although ROR¥á contributes to overall fitness among anticancer, anti-inflammatory, lipid homeostasis, and circadian clock mechanisms, the molecular mechanisms underlying the mode of transcriptional regulation by ROR¥á remain unclear. Nonetheless, ROR¥á has important implications for pharmacological prevention of cancer, inflammation, and metabolic diseases, and understanding context-dependent ROR¥á regulation will provide an innovative approach for unraveling the functional link between cancer metabolism and rhythm changes.
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KEYWORD
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Cell signalling, Transcriptional regulatory elements
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